Prognostic impact of osteosarcopenia on postoperative outcomes in patients with biliary tract cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Osteosarcopenia, the combination of sarcopenia and osteopenia, predicts poor survival in patients undergoing biliary tract cancer resection. This finding highlights osteosarcopenia as a crucial prognostic factor for adverse outcomes post-surgery.
Area Of Science
- Oncology
- Geriatrics
- Radiology
Background
- Frailty, encompassing sarcopenia and osteopenia, is linked to reduced survival in biliary tract cancer (BTC) patients post-resection.
- Osteosarcopenia, the concurrent presence of sarcopenia and osteopenia, has emerged as a predictor of poor outcomes in various cancer types.
Purpose Of The Study
- To evaluate the prognostic significance of osteosarcopenia in patients who have undergone resection for biliary tract cancer.
- To determine if osteosarcopenia is an independent predictor of survival after BTC surgery.
Main Methods
- A cohort of 109 patients who underwent BTC resection between 2014 and 2021 were analyzed.
- Sarcopenia was assessed via psoas muscle computed tomography, and osteopenia via bone mineral density measurements.
- Osteosarcopenia was defined as the simultaneous presence of both sarcopenia and osteopenia.
Main Results
- The study found sarcopenia in 50% of patients, osteopenia in 46%, and osteosarcopenia in 28%.
- Osteosarcopenia was associated with a higher incidence of lymph node metastasis.
- Multivariate analysis identified osteosarcopenia, lymph node metastasis, and poor tumor differentiation as independent predictors of poor disease-free survival.
Conclusions
- Osteosarcopenia is a significant prognostic factor for unfavorable outcomes following biliary tract cancer resection.
- The presence of osteosarcopenia independently predicts poor disease-free and overall survival in BTC patients.
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