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Updated: Jun 6, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Peripartum Depression: What's New?

Lisa Vitte1,2, Sandra Nakić Radoš3, Mijke Lambregtse-van den Berg4

  • 1Service Universitaire de Pédopsychiatrie, Hospital Group Du Havre, University Rouen Normandy, Le Havre, France.

Current Psychiatry Reports
|December 3, 2024
PubMed
Summary

Peripartum depression (PPD) is a common perinatal health issue impacting families. Understanding its complex causes and effects is crucial for improving diagnosis and infant development outcomes.

Keywords:
Offspring emotional developmentPPD diagnosisParent-infant interactionPerinatal psychiatryPeripartum depression

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Area of Science:

  • Perinatal mental health
  • Reproductive psychiatry
  • Developmental psychology

Background:

  • Peripartum depression (PPD) is the most frequent health disorder during pregnancy and postpartum.
  • PPD is a significant public health concern due to its prevalence and impact on women, partners, and offspring.
  • Recent research highlights the heterogeneity of PPD and its complex pathophysiology.

Purpose of the Study:

  • To review the latest studies and publications on peripartum depression (PPD) in 2024.
  • To consolidate essential knowledge regarding PPD as a specific perinatal issue.
  • To address the public health significance of PPD.

Main Methods:

  • Comprehensive literature review of recent studies on PPD.
  • Analysis of publications focusing on PPD pathophysiology, severity, and co-morbidities.
  • Synthesis of evidence on the impact of PPD on parent-infant interactions and child development.

Main Results:

  • PPD is a heterogeneous disorder resulting from a complex interplay of factors.
  • Enhanced diagnosis and referral are critical public health priorities.
  • PPD negatively impacts parent-infant interactions and infant cognitive, social, and emotional development.
  • Significant evidence of global risk for PPD has accumulated over three decades.

Conclusions:

  • A deeper understanding of PPD's severity and co-morbidities is essential for improving care.
  • Addressing PPD is vital for mitigating negative impacts on offspring development.
  • Further research is needed to understand the long-term developmental trajectories of offspring affected by PPD.