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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Targeting Immune Cells.

Emilie Seydoux1, Kleanthis Fytianos1, Christophe von Garnier1

  • 1Department of Biomedical Research, University of Bern, Bern, Switzerland.

Journal of Aerosol Medicine and Pulmonary Drug Delivery
|December 3, 2024
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Summary
This summary is machine-generated.

Inhaled nanoparticles offer targeted delivery for lung immune modulation, potentially treating or preventing pulmonary diseases. Careful analysis of nanocarrier immunomodulatory effects is crucial for developing effective inhaled therapies.

Keywords:
dendritic cellsimmunityimmunomodulationimmunotherapyinhalation therapynanoparticles

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Area of Science:

  • Pulmonary immunology
  • Nanomedicine
  • Drug delivery systems

Background:

  • The respiratory tract's large surface area and thin barrier facilitate interaction with inhaled substances.
  • Pulmonary immune cells like epithelial cells, macrophages, and dendritic cells are crucial for innate and adaptive immunity.
  • These frontline immune cells exhibit diverse characteristics based on lung compartment, making them ideal targets for inhaled immunomodulators.

Purpose of the Study:

  • To explore the potential of nanosized carriers for pulmonary immunomodulation via inhalation.
  • To investigate how targeting specific lung immune cells with nanocarriers can modulate immune responses.
  • To highlight the role of nanocarriers in both prophylactic and therapeutic strategies for pulmonary diseases.

Main Methods:

  • Targeting specific immunocompetent cells within the lung using potent carriers.
  • Modulating immune cell-antigen interactions, including uptake, trafficking, processing, and presentation.
  • Utilizing the deposition and targeting properties of nanoparticles for localized or systemic immune response modulation.

Main Results:

  • Inhalation of nanosized carriers demonstrates potential for both prophylactic and therapeutic applications.
  • Nanoparticle-triggered immune responses can be either immunostimulatory or immunosuppressive.
  • Targeting specific cell populations or lung compartments can trigger or modulate immune responses.

Conclusions:

  • Nanosized carriers are promising for pulmonary immunomodulation, offering targeted delivery for treating and preventing lung diseases.
  • Thorough evaluation of nanocarrier immunomodulatory, pharmacological, and toxicological properties is essential.
  • Interdisciplinary collaboration is key for designing and characterizing effective inhalable nanocarriers for pulmonary applications.