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Updated: Jun 6, 2025

A Facile and Efficient Approach for the Production of Reversible Disulfide Cross-linked Micelles
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Published on: December 23, 2016

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An innovative strategy for radical-mediated, bidirectional controlled disulfide exchange

Bohan Li1,2, Zhenguo Zhang1,2, Raymond Tio2

  • 1College of Advanced Interdisciplinary Science and Technology, Henan University of Technology, Zhengzhou 450001, China.

Proceedings of the National Academy of Sciences of the United States of America
|December 3, 2024
PubMed
Summary

This study introduces a new radical-initiated method for reversible disulfide metathesis under biocompatible conditions. The technique enables precise modifications of biomolecules like proteins and drugs, advancing chemical biology and therapeutic development.

Keywords:
biocompatibledisulfide metathesishydroxy(tosyloxy)-iodobenzeneradical pathwayreversible

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