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Nectin-4 Positivity in Genitourinary Malignancies: A Systematic Review
Emanuele Crupi1,2, Tiago Costa de Padua1, Laura Marandino1
1Department of Medical Oncology, IRCCS San Raffaele Hospital, Milan, Italy.
JCO Precision Oncology
|December 3, 2024
Summary
Nectin-4 (N4) is highly expressed in urothelial carcinoma of the bladder (UBC), particularly in metastatic stages. Non-urothelial genitourinary cancers generally show lower N4 positivity, suggesting N4 as a potential target for UBC therapies.
Area of Science:
- Oncology
- Genitourinary Cancer Research
- Molecular Diagnostics
Background:
- Aberrant nectin-4 (N4) expression is identified in various cancers, positioning it as a promising target for antibody-drug conjugates.
- N4 is particularly relevant in urothelial carcinoma of the bladder (UBC), but data on its prevalence in other genitourinary (GU) malignancies are scarce.
Conclusions:
- Non-urothelial genitourinary (GU) cancers generally demonstrate lower nectin-4 (N4) positivity than urothelial carcinoma (UC).
- N4 expression in bladder cancer varies with tumor stage and the presence of histologic subtypes (HS).
- Further prospective studies are warranted to fully elucidate the predictive and prognostic significance of N4 in GU malignancies.
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