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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
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Major Hormones and Their Functions01:27

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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
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Related Experiment Video

Updated: Jun 6, 2025

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
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Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

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Pergolide mesylate administration does not decrease blood thyroid hormone concentrations and thyroid function in

Martyna M Jargielo, Janice E Kritchevsky, François-René Bertin

    American Journal of Veterinary Research
    |December 3, 2024
    PubMed
    Summary
    This summary is machine-generated.

    Pergolide treatment did not affect equine thyroid function or blood thyroid hormone levels. Low thyroid hormone concentrations in horses with pituitary pars intermedia dysfunction are likely due to the condition itself.

    Keywords:
    endocrinologyhypothyroidismnonthyroid illness syndromepituitary pars intermedia dysfunctionthyrotropin-releasing hormone

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    Area of Science:

    • Equine endocrinology
    • Veterinary pharmacology

    Background:

    • Pergolide is used to treat pituitary pars intermedia dysfunction in horses.
    • It is highly protein-bound, raising concerns about potential displacement of thyroid hormones.

    Purpose of the Study:

    • To investigate the effect of pergolide on equine thyroid function.
    • To determine if pergolide alters blood thyroid hormone concentrations.

    Main Methods:

    • An observational cohort study involving six horses treated with pergolide.
    • Thyroid hormone levels (total T4, total T3, free T4) were measured before, during, and after treatment.
    • Thyrotropin-releasing hormone (TRH) stimulation tests were performed.

    Main Results:

    • Pergolide administration did not significantly alter total T4 levels.
    • TRH stimulation caused expected increases in thyroid hormones.
    • No significant effect of pergolide on any measured thyroid hormone concentration was observed.

    Conclusions:

    • Pergolide does not appear to affect thyroid hormone concentrations in horses.
    • Observed low thyroid hormone levels in horses with pituitary pars intermedia dysfunction are likely related to the disease, not the medication.