Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of diuretics on endolymphatic hydrops.

H Shinkawa, R S Kimura

    Acta Oto-Laryngologica
    |January 1, 1986
    PubMed
    Summary

    Acetazolamide reduced endolymphatic hydrops in guinea pigs during treatment, but the effect ceased after discontinuation. Chlorthalidone showed no significant impact on hydrops, suggesting alternative mechanisms for Meniere

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Association between skin suture devices and incidence of incisional surgical site infection after gastrointestinal surgery: systematic review and network meta-analysis.

    The Journal of hospital infection·2024
    Same author

    The effectiveness of fascial closure with antimicrobial-coated sutures in preventing incisional surgical site infections in gastrointestinal surgery: a systematic review and meta-analysis.

    The Journal of hospital infection·2023
    Same author

    Postoperative loss of independence 1 year after liver resection: prospective multicentre study.

    The British journal of surgery·2022
    Same author

    Cochlear outer hair cells in a dominant-negative connexin26 mutant mouse preserve non-linear capacitance in spite of impaired distortion product otoacoustic emission.

    Neuroscience·2009
    Same author

    Influence of Carisolv on resin adhesion for two different adhesive systems to sound human primary dentin and young permanent dentin.

    Journal of dentistry·2005
    Same author

    Genetic features of hearing loss associated with ear anomalies: PDS and EYA1 mutation analysis.

    Journal of human genetics·2001

    Area of Science:

    • Otolaryngology
    • Pharmacology
    • Inner Ear Physiology

    Background:

    • Endolymphatic hydrops is a condition characterized by fluid buildup in the inner ear.
    • Diuretics are often considered for Meniere's disease symptom management.
    • The direct effect of diuretics on endolymphatic hydrops requires further investigation.

    Purpose of the Study:

    • To evaluate the efficacy of acetazolamide and chlorthalidone in reducing endolymphatic hydrops.
    • To determine if diuretic treatment impacts cochlear pathology associated with hydrops.

    Main Methods:

    • Endolymphatic hydrops was induced in guinea pigs by obliterating the endolymphatic duct and sac.
    • Animals were treated with varying doses of acetazolamide or chlorthalidone.
    • Volumetric changes in the scala media were statistically analyzed to assess hydrops severity.

    Main Results:

    • Acetazolamide administration reduced endolymphatic hydrops during the treatment period (30 days).
    • The hydrops reduction effect of acetazolamide was not sustained after drug withdrawal.
    • Chlorthalidone did not show a statistically significant effect on endolymphatic hydrops.
    • No significant difference in cochlear sensory and neural atrophy was observed between treated and untreated animals.

    Conclusions:

    • Acetazolamide demonstrates a temporary, dose-dependent effect on reducing endolymphatic hydrops.
    • Chlorthalidone's therapeutic benefits in Meniere's disease likely involve mechanisms other than direct hydrops reduction.
    • Diuretic treatment did not prevent secondary cochlear degeneration in this model.

    Related Experiment Videos