Fine structure of the rat tympanic membrane after treatment with local anaesthetics

The tympanic membrane of the rat was studied ultrastructurally after application of a local anaesthetic--lidocaine spray. Already after 10 min, degenerative changes--or even necrosis--were observed on both epithelial surfaces of the eardrum. Later on, a marked hyperplasia of the epidermal layer was most characteristic, as was a proliferation of the fibroblasts of the subepithelial connective tissue. After 3 weeks the eardrum had not regained its normal appearance. No perforations were encountered and only minute substructural changes could be detected within the fibrous layer.