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Reye's syndrome in Denmark. A retrospective study.

P Daugbjerg, L Ranek

    Acta Paediatrica Scandinavica
    |March 1, 1986
    PubMed
    Summary

    This study investigated Reye's syndrome (RS) incidence in Denmark during a 1979 influenza B epidemic. Researchers found a very low incidence of RS in children, suggesting unique factors may be at play.

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    Area of Science:

    • Pediatrics
    • Epidemiology
    • Virology

    Background:

    • Reye's syndrome (RS) is a rare but serious condition often linked to influenza B infections in children.
    • Denmark experienced a significant influenza B epidemic in 1979, providing a relevant period for incidence study.
    • Previous studies suggest varying RS incidence globally, necessitating country-specific data.

    Purpose of the Study:

    • To determine the incidence of Reye's syndrome (RS) in Denmark.
    • To assess the potential association between the 1979 influenza B epidemic and RS cases.
    • To establish a baseline incidence rate for RS in the Danish pediatric population.

    Main Methods:

    • Retrospective study design analyzing mortality data in children aged 1 month to 18 years in Denmark during 1979.
    • Exclusion of deaths from accidents or malignant diseases to focus on potential RS cases.
    • Review of hospital records, death certificates, and autopsy reports, supplemented by inquiries to pediatric departments.

    Main Results:

    • One confirmed case of Reye's syndrome was identified among 242 hospital deaths.
    • No cases meeting RS criteria were found among 105 deaths outside hospitals.
    • Pediatric departments reported no RS diagnoses during the study period.

    Conclusions:

    • The incidence of Reye's syndrome in Denmark in 1979 was found to be extremely low (0.09 per 100,000 children aged 1-14).
    • The low incidence suggests potential unknown factors influencing Reye's syndrome occurrence in Denmark.
    • Further research is warranted to understand the reasons behind the low observed incidence.

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