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Extracellular vesicle-packed microRNAs profiling in Alzheimer's disease: The molecular intermediary between pathology

Sandila Arif1, Talal Jamil Qazi2, Zhenzhen Quan1

  • 1Key Laboratory of Molecular Medicine and Biotherapy, Department of Biology, School of Life Science, Beijing Institute of Technology, Beijing 100081, China.

Ageing Research Reviews
|December 3, 2024
PubMed

Insights

MicroRNAs (miRNAs) are implicated in Alzheimer's disease (AD) pathology. This review explores how EV-packed miRNAs can serve as potential biomarkers for early AD diagnosis.

Area of Science:

  • Biochemistry
  • Neuroscience
  • Genetics

Background:

  • MicroRNAs (miRNAs) are non-coding RNAs involved in biological processes.
  • miRNAs contribute to Alzheimer's disease (AD) pathophysiology via amyloid-beta production, Tau phosphorylation, and neuroinflammation.
  • Extracellular vesicles (EVs) transport biomarkers from the brain to peripheral blood.

Purpose of the Study:

  • To systematically review the roles of miRNAs in AD.
  • To explore the potential of EV-packed miRNAs as biomarkers for early AD diagnosis.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of miRNA functions in AD pathogenesis.
  • Evaluation of EV-mediated miRNA transport and diagnostic potential.

Main Results:

  • miRNAs play a significant role in AD development.
  • EVs encapsulate miRNAs, offering a route for biomarker discovery.
  • EV-packed miRNAs show promise for non-invasive AD detection.

Conclusions:

  • EV-packed miRNAs represent a promising avenue for advancing AD understanding.
  • Further research is crucial to validate the diagnostic potential of EV-miRNAs for early AD detection.
Keywords:
Alzheimer's diseaseBiomarkersExtracellular vesiclesMicroRNAsNeurodegenerationTherapeutic targets

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