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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Related Experiment Video

Updated: May 12, 2026

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
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Optimal Therapy for Postoperative Recurrence: Does Salvage Radiation Work for Locoregional Recurrence?

Yuri Taniguchi1, Takao Shigenobu2, Akiko Hayashi3

  • 1Department of Respiratory Medicine, Yokohama Municipal Citizen's Hospital, Yokohama, Japan; yuriteito@gmail.com.

Anticancer Research
|December 3, 2024
PubMed
Summary

Patients with non-small-cell lung cancer (NSCLC) recurrence after surgery have better survival with locoregional recurrence. Salvage local therapy, including radiotherapy (RT) and concurrent chemoradiotherapy (cCRT), shows promise for treating locoregional recurrence.

Keywords:
EGFRLocoregional recurrenceconcurrent chemoradiotherapysalvage local therapy

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Area of Science:

  • Oncology
  • Thoracic Surgery
  • Radiation Oncology

Background:

  • Outcomes for non-small-cell lung cancer (NSCLC) patients with successful resection are not fully understood.
  • Optimal treatment for postoperative locoregional recurrence remains undefined.

Purpose of the Study:

  • To analyze survival outcomes in NSCLC patients post-resection.
  • To evaluate the efficacy of salvage local therapies for locoregional recurrence.

Main Methods:

  • Retrospective review of 694 NSCLC patients undergoing R0 resection (2013-2022).
  • Analysis of survival based on locoregional versus distant recurrence.
  • Evaluation of radiotherapy (RT) and concurrent chemoradiotherapy (cCRT) for locoregional recurrence.

Main Results:

  • 150 of 694 patients experienced recurrence (54 locoregional, 96 distant).
  • Median overall survival (OS) was significantly better for locoregional recurrence (55.9 months) vs. distant recurrence (22.3 months).
  • Salvage local therapy (cCRT/RT) for locoregional recurrence yielded median PFS of 13.3 and OS of 60.4 months with good tolerability.

Conclusions:

  • Locoregional recurrence in NSCLC after resection has a better prognosis than distant recurrence.
  • Salvage local therapy, including cCRT and RT, is a potentially effective and tolerable treatment for locoregional recurrence.