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Somatosensory evoked potentials: technique, interpretation and clinical applications
Aicee Dawn Calma1,2, James Triplett3,4, Steve Vucic1,2,5
1Brain and Nerve Research Centre, Concord Hospital, Concord, New South Wales, Australia.
Practical Neurology
|December 3, 2024
Summary
Somatosensory evoked potentials (SSEPs) assess sensory pathway function by measuring electrical activity after nerve stimulation. SSEPs provide valuable clinical insights, especially when imaging is inconclusive for nervous system disorders.
Area of Science:
- Neuroscience
- Neurophysiology
- Clinical Electrophysiology
Background:
- Somatosensory evoked potentials (SSEPs) are crucial for evaluating the ascending somatosensory pathways.
- They involve stimulating mixed nerves and recording subsequent sensory nerve responses.
- SSEPs offer complementary data to clinical exams and imaging studies.
Purpose of the Study:
- To detail the technique and anatomical basis of SSEP waveforms.
- To highlight the clinical utility of SSEPs in neurological assessments.
- To underscore the role of SSEPs in diagnosing central and peripheral nervous system disorders.
Main Methods:
- Elicitation of SSEPs through mixed nerve stimulation.
- Orthodromic stimulation of sensory nerves.
- Analysis of waveform components and their anatomical correlates.
Main Results:
- SSEPs effectively measure the functional integrity of somatosensory pathways.
- Waveform analysis provides insights into specific neural structures.
- Clinical applications span various central and peripheral nervous system conditions.
Conclusions:
- SSEPs are indispensable for comprehensive neurophysiological assessment.
- They are particularly valuable when neuroimaging is inconclusive.
- SSEPs enhance diagnostic capabilities for a range of neurological disorders.

