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Hidradenitis suppurativa pathogenesis: Extrinsic factors
Valdemar Wendelboe Nielsen1, Simon Francis Thomsen2, Haley B Naik3
1Department of Dermato-Venereology & Wound Healing Centre, Copenhagen University Hospital - Bispebjerg & Frederiksberg, Copenhagen, Denmark.
Journal of the American Academy of Dermatology
|December 3, 2024
Summary
Extrinsic factors like smoking, diet, and microbiome changes significantly impact hidradenitis suppurativa (HS) development and progression. Addressing these lifestyle elements alongside genetics may improve HS management and outcomes.
Area of Science:
- Dermatology
- Immunology
- Microbiome Research
Background:
- Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition.
- Genetic predisposition and immune dysregulation are established contributors to HS.
- Emerging evidence highlights the role of external factors in HS pathogenesis.
Purpose of the Study:
- To review the influence of extrinsic factors on hidradenitis suppurativa.
- To explore the impact of mechanical stress, microbiome alterations, smoking, diet, and drug reactions on HS onset and progression.
Main Methods:
- Literature review synthesizing current research on extrinsic factors in HS.
- Analysis of studies investigating the relationship between lifestyle and environmental factors and HS.
Main Results:
- Mechanical stress, altered skin and gut microbiomes, tobacco smoking, diet, and paradoxical drug reactions are identified as potential drivers of HS.
- These extrinsic factors appear to influence both the initiation and worsening of the condition.
Conclusions:
- A comprehensive management strategy for HS should consider extrinsic factors.
- Further research is essential to elucidate the causal links between these factors and HS, informing future treatment strategies.
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