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Related Concept Videos

Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

309
Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
309

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Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
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Shape Effect of Polymer-Based Multilayer Microcapsules on Cellular Internalization.

Xiaoqiang Zhang1,2,3, Jianmei Han2, Ting Ding1

  • 1Joint Research Centre on Medicine, Xiangshan Hospital of Wenzhou Medical University, Ningbo, Zhejiang 315700, China.

Langmuir : the ACS Journal of Surfaces and Colloids
|December 3, 2024
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Summary
This summary is machine-generated.

Microcapsule shape significantly impacts cellular uptake. Dumbbell and cubic shapes show higher internalization rates than spherical ones, offering insights for drug carrier development.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Biomedical Engineering

Background:

  • The intracellular fate of drug carriers is crucial for their efficacy.
  • Carrier shape influences cellular uptake, but research is limited by preparation challenges.

Purpose of the Study:

  • To engineer polymer-based microcapsules with defined shapes (spherical, peanut, dumbbell, cubic).
  • To investigate the effect of microcapsule shape on cellular internalization kinetics and mechanisms.

Main Methods:

  • Fabrication of microcapsules using layer-by-layer assembly on CaCO3 templates.
  • Characterization of microcapsule shape and surface chemistry using SEM, CLSM, AFM, FTIR, and XPS.
  • Evaluation of cellular internalization rates and mechanisms in various cell lines.

Main Results:

  • Successfully synthesized microcapsules with distinct shapes and uniform surface chemistry (PEI/PEG).
  • Dumbbell and cubic microcapsules demonstrated significantly higher cellular internalization rates and amounts compared to spherical and peanut shapes.
  • Cellular uptake was primarily mediated by micropinocytosis, irrespective of microcapsule shape.

Conclusions:

  • Microcapsule shape is a critical determinant of cellular internalization efficiency.
  • Engineered microcapsules with specific shapes (dumbbell, cubic) can enhance drug delivery potential.
  • This study provides valuable data for designing advanced drug delivery systems based on microcapsule morphology.