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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Hematopoiesis01:21

Hematopoiesis

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The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the...
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Updated: Jun 5, 2025

Bioengineering of Humanized Bone Marrow Microenvironments in Mouse and Their Visualization by Live Imaging
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Cellular crosstalk in the bone marrow niche.

Zeqi Huang1, Zoya Iqbal1, Zhe Zhao1

  • 1Hand and Foot Surgery Department, Shenzhen Second People's Hospital (The First Hospital Affiliated to Shenzhen University), 3002 Sungang West Road, Shenzhen, 518000, China.

Journal of Translational Medicine
|December 4, 2024
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The bone marrow niche is a complex microenvironment where cells like hematopoietic stem cells interact. Understanding this cellular crosstalk is key to regulating bone repair and developing new therapies.

Keywords:
Bone marrowBone reconstruction and repairHaematopoietic stem cellsNiche

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Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
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Automated Quantification of Hematopoietic Cell – Stromal Cell Interactions in Histological Images of Undecalcified Bone
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Area of Science:

  • Cell Biology
  • Hematology
  • Immunology

Background:

  • The bone marrow niche is a specialized microenvironment essential for maintaining hematopoietic stem cell function.
  • Cellular interactions within the niche regulate bone reconstruction and repair.
  • Existing knowledge on the intricate crosstalk among bone marrow niche components is incomplete.

Purpose of the Study:

  • To elaborate on the crosstalk between various cellular components in the bone marrow niche.
  • To explain mechanisms preserving bone marrow niche equilibrium for bone repair.
  • To review new immunotherapies for bone tumors within the bone marrow niche.

Main Methods:

  • Literature review focusing on cellular interactions within the bone marrow niche.
  • Analysis of mechanisms regulating bone marrow niche equilibrium.
  • Discussion of intercommunications among osteocytes, lymphocytes, megakaryocytes, macrophages, and mesenchymal stem cells.
  • Exploration of novel immunotherapies for bone tumors.

Main Results:

  • Detailed elucidation of crosstalk between hematopoietic stem cells and other niche cells.
  • Explanation of mechanisms for maintaining bone marrow niche homeostasis.
  • Identification of specific cell interactions: osteocyte communication, lymphocyte regulation of osteoblasts, megakaryocyte deficiency impact, and macrophage-mesenchymal stem cell interaction.
  • Discussion of emerging immunotherapies targeting the bone marrow niche.

Conclusions:

  • The bone marrow niche involves complex cellular crosstalk crucial for hematopoiesis and bone homeostasis.
  • Understanding these interactions provides insights into bone reconstruction and repair mechanisms.
  • This review highlights the therapeutic potential of targeting bone marrow niche cells for various diseases and bone tumors.