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Monitoring Spatial Segregation in Surface Colonizing Microbial Populations

Monitoring Spatial Segregation in Surface Colonizing Microbial Populations

Published on: October 29, 2016

Bactogram: Spatial Analysis of Bacterial Colonisation in Epidermal Wounds.

Karl Wallblom^1,2, Fredrik Forsberg¹, Sigrid Lundgren^1,2

¹Division of Dermatology and Venereology, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Experimental Dermatology

|December 4, 2024

Summary

A new Bactogram method visually maps bacteria on skin and wounds, aiding in understanding infections and atopic dermatitis. This technique allows for spatial quantification of bacterial colonization during wound healing.

Keywords:

Staphylococcus aureus clinical study microbiology wound healing wound infection

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Area of Science:

Microbiology
Dermatology
Wound Healing

Background:

Skin barrier damage facilitates harmful microbiota, leading to conditions like wound infections and atopic dermatitis.
Current microbial sampling methods (swabs, biopsies) lack spatial distribution data.
Millions are affected by these conditions, causing significant healthcare costs.

Purpose of the Study:

Introduce a novel method, 'Bactogram', for visualizing cultivable bacteria distribution on skin and wounds.
Enable image-based quantification of bacterial presence and spatial variation.
Assess the utility of Bactogram in characterizing bacterial re-colonization during wound healing.

Main Methods:

Developed the 'Bactogram' method to create visual maps of bacterial distribution on skin and wounds.
Applied the Bactogram method to 48 suction blister wounds in 24 healthy volunteers.
Utilized visual scoring and image analysis for bacterial quantification, assessing inter- and intra-rater reliability.

Main Results:

Bacteria were present in all wounds, primarily under dressings and near wound edges.
Quantification methods showed high agreement, characterizing bacterial re-colonization during healing.
Demonstrated proof of concept for spatial identification of specific pathogens like Staphylococcus aureus using chromogenic agar.

Conclusions:

The Bactogram method offers a simple approach for large-area bacterial sampling.
Generates bacterial maps to identify spatial variations in composition and abundance.
Provides a valuable tool for studying skin and wound microbial conditions.