Textbook Outcomes and Quality of Life Assessment Following Liver Resection for Colorectal Metastasis

It is unknown if textbook outcomes (TBOs) correlate with patient-reported health-related quality of life (HRQoL) parameters in patients undergoing hepatic resection for colorectal liver metastasises. Understanding this relationship is required to inform treatment decisions and optimise patient care. This single-centre analysis aims to assess this correlation and provide insight into the impact of liver resection on patient well-being in this population.

Single-centre analysis of all liver resections performed for colorectal liver metastases (CRLM) at our centre from 2018 to 2023. The EuroQol-5D (EQ-5D) validated telephone questionnaire was used to assess HRQoL. The impact of a TBO on overall survival and recurrence-free survival was investigated using Kaplan-Meier curve analysis. A Cox model was used to determine factors associated with improved survival.

185 patients underwent liver resection for CRLM between 2018 and 2023. 55% of eligible patients completed the EQ-5D telephone questionnaire. TBOs were achieved in 68.2% of CRLM at our institution. Achieving TBOs in this cohort was associated with improved HRQoL (p = 0.061).

This study demonstrates excellent long-term HRQoL in patients who undergo resection for CRLM. Achieving TBO in this cohort is associated with improved patient-reported HRQoL. Our findings strengthen the utility of the previously defined textbook outcomes in CRLM.