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Updated: Jul 23, 2026

A Method for Selecting Structure-switching Aptamers Applied to a Colorimetric Gold Nanoparticle Assay
Published on: February 28, 2015
Organomercury oligonucleotide-polydopamine nanoparticle assemblies discriminate between target sequences by
Tharun K Kotammagari1, Majid Al-Waeel1, Jukka Lukkari1
1Department of Chemistry, University of Turku Henrikinkatu 2 20500 Turku Finland tuanlo@utu.fi.
Abstract:
A fluorescently tagged oligonucleotide hybridization probe incorporating a single 5-mercuricytosine residue was synthesized and found to adsorb on polydopamine nanoparticles much more strongly than its unmetallated counterpart. Hybridization with target sequences led to release of the probe from the nanoparticle to varying degrees depending on the nucleobase opposite to 5-mercuricytosine.
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