Non-coding RNAs in bladder cancer, a bridge between gut microbiota and host?

Area of Science:

• Oncology
• Microbiology
• Genetics

Background:

• Gut microbiota (GM) plays a significant role in bladder cancer (BC) development and impacts treatment efficacy.
• Interventions targeting GM are underutilized in BC due to complex host-microbiota interactions.
• Aberrantly expressed non-coding RNAs (ncRNAs) are implicated in BC progression, including proliferation, invasion, and drug resistance.

Purpose of the Study:

• To analyze ncRNAs associated with GM in bladder cancer.
• To summarize the role of GM-ncRNA interactions in BC phenotypes.
• To delineate the regulatory network between GM and ncRNAs for novel therapeutic strategies.

Main Methods:

• Literature review focusing on ncRNAs and gut microbiota in bladder cancer.
• Analysis of existing research on GM-mediated epigenetic regulation by ncRNAs.
• Synthesis of findings to illustrate the interplay between GM, ncRNAs, and BC.

Main Results:

• GM influences bladder carcinogenesis and adjuvant therapy response.
• ncRNAs are emerging as key mediators in GM-driven epigenetic regulation.
• Specific ncRNAs are closely linked to GM in the context of BC occurrence and treatment.

Conclusions:

• The interaction between GM and ncRNAs offers a new perspective for understanding and treating bladder cancer.
• Targeting the GM-ncRNA regulatory network may provide novel therapeutic avenues.
• Further research into this interplay is crucial for advancing bladder cancer prevention and management.