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Related Concept Videos

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

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Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
248
Antiepileptic Drugs: Sodium Channel Blockers01:08

Antiepileptic Drugs: Sodium Channel Blockers

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Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
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Comparative Lesions Analysis Through a Targeted Sequencing Approach
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A Singular Case Analysis: Lamotrigine-Associated Stevens-Johnson Syndrome.

Albin Joshi1, Anjula Palikhe1, Santosh Acharya2

  • 1Department of Pharmacy, KIST Medical College and Teaching Hospital, Imadol, Lalitpur, Nepal.

Case Reports in Critical Care
|December 4, 2024
PubMed
Summary

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug reactions. Early identification and withdrawal of lamotrigine, alongside prompt supportive care, led to significant patient improvement.

Area of Science:

  • Pharmacology
  • Dermatology
  • Immunology

Background:

  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe, immune-mediated hypersensitivity reactions.
Keywords:
Stevens–Johnson syndrome (SJS)adverse drug reaction (ADR)antiepileptic drugscase reportlamotriginetoxic epidermal necrolysis (TEN)

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  • These reactions are frequently associated with adverse drug effects, with reported cases in Nepal.
  • Lamotrigine is a known causative agent for SJS/TEN.