Coexistence of Pemphigus Foliaceus and Bullous Pemphigoid: A Case Report

Pemphigus foliaceus (PF) and bullous pemphigoid (BP) are distinct autoimmune bullous skin diseases mediated by autoantibodies targeting adhesion molecules in desmosomes and hemidesmosomes structural proteins in the epidermal-basement membrane zone, respectively. The coexistence of PF and BP is rare. We present the case of a 72-year-old male with clinical and histological features of both PF and BP. Treatment with immunoglobulin (10 g/day for 3 days), intravenous dexamethasone sodium phosphate (5 mg/day for 10 days), oral triamcinolone (30 mg/day for 10 days), and minocycline hydrochloride (20 mg/day for 10 days) resulted in significant improvement. This rare case highlights the importance of accurate diagnosis and effective treatment strategies for the coexistence of PF and BP.