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Updated: Jun 5, 2025

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Published on: July 7, 2020
Mechanisms of tigecycline resistance in Gram-negative bacteria: A narrative review
Wenya Su1, Wenjia Wang1, Ling Li1
1State Key Laboratory of Microbial Technology, Microbial Technology Institute, Shandong University, Qingdao 266237, PR China.
Abstract:
Tigecycline serves as a critical "final-resort" antibiotic for treating bacterial infections caused by multidrug-resistant bacteria for which treatment options are severely limited. The increasing prevalence of tigecycline resistance, particularly among Gram-negative bacteria, is a major concern. Various mechanisms have been identified as contributors to tigecycline resistance, including upregulation of nonspecific Resistance Nodulation Division (RND) efflux pumps due to mutations in transcriptional regulators, enzymatic modification of tigecycline by monooxygenase enzymes, and mutations affecting tigecycline binding sites. This review aims to consolidate our understanding of tigecycline resistance mechanisms in Gram-negative bacteria and offer insights and perspectives for further drug development.
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