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Updated: Jun 5, 2025

Analysis of Autophagy in Penicillium chrysogenum by Using Starvation Pads in Combination With Fluorescence Microscopy
Published on: February 1, 2015
Penicichrysol A: an unprecedented polyketide produced by Penicillium chrysogenum
Shuyuan Mo1,2, Zhihong Huang1, Hanxiao Zeng1
1Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. hzx616@126.com.
Abstract:
Penicichrysol A (1), a highly oxygenated polyketide with an unprecedented skeleton, uniquely defined by multiple contiguous quaternary carbons, was isolated as a racemate from an endophytic fungus Penicillium chrysogenum that was sourced from the bulbs of the medicinal plant Lycoris radiata. Besides, three known biosynthetically related metabolites 2-4 were also obtained. The structure including the configuration of 1 was established via a combination of NMR spectroscopy and single-crystal X-ray diffraction analysis. A plausible biosynthetic pathway involving intriguing radical coupling and hemiketal reactions as key chemical transformations has been proposed.
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