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Updated: Jun 5, 2025

A Protocol for Safe Lithiation Reactions Using Organolithium Reagents
Published on: November 12, 2016
Selective lithium halide ion-pair sensing by a dynamic metalloporphyrin [2]rotaxane
Jamie T Wilmore1, Andrew Docker2, Paul D Beer1
1Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK. paul.beer@chem.ox.ac.uk.
Abstract:
A dynamic zinc(II) metalloporphyrin axle-containing [2]rotaxane with a heteroditopic macrocycle component is shown to selectively recognise and optically sense lithium halide (LiX) ion-pair species. 1H NMR and UV-visible absorption experiments demonstrate a strong macrocycle pyridyl⋯Zn(II) metalloporphyrin axle interaction which results in a marked co-conformational bias in the free [2]rotaxane host system. Extensive 1H NMR cation, anion and ion-pair titration experiments demonstrate the binding of lithium halide ion-pairs disrupts the inter-component mechanical bond interaction, wherein dynamic macrocycle shuttling to an axle triazole station enables co-operative axle-separated LiX ion-pair recognition and the selective optical sensing of lithium halide salts.
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