Amyloid light chain and amyloid A protein, two types of gastrointestinal amyloidosis
Maki Setake1, Keisuke Yonamine1, Kyoko Arakaki2
1Gastroenterology, Naha City Hospital, Japan.
Abstract:
We have encountered rare cases of two types of gastrointestinal amyloidosis, amyloid light chain (AL) type and amyloid A protein (AA) type. Case 1: An 83-year-old man developed hematochezia after percutaneous coronary intervention. CT scans showed wall thickening of the colon. Colonoscopy revealed submucosal tumor-like protrusions with ulceration in the colon. Biopsies confirmed the diagnosis of colonic amyloidosis. Multiple myeloma-associated AL amyloidosis was suspected based on positive serum M-protein. Case 2: A 79-year-old woman with rheumatoid arthritis (RA) underwent esophagogastroduodenoscopy, which revealed multiple gastric erosions. Biopsies showed amyloidosis. AA amyloidosis with underlying RA was suspected.
Related Concept Videos
Amyloid Fibrils
Amyloid deposits were observed as early as 1639 in the liver and the spleen. In 1854, Rudolph Virchow performed iodine staining,...
Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Protein Absorption
Actin Polymerization and Cell Motility
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
Introduction to Actin


