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ATF4 Exacerbates Cerebral Infarction-Induced Sensory Dysfunction via HDAC1/DNMT1/GPX4 Signaling

Bingtuan Lu1, Ninghui Mu1, Pu Li2

  • 1Department of General Practice, The First People's Hospital of Yunnan Province, 650032, China; The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, China.

Critical Reviews in Eukaryotic Gene Expression
|December 4, 2024
PubMed
Summary

Activating transcription factor 4 (ATF4) exacerbates cerebral infarction and sensory dysfunction. Reducing ATF4 levels protects brain tissue and restores function by inhibiting ferroptosis via DNMT1-mediated GPX4 regulation.

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