Fe(II)-Iminopyridine Catalyst for the Regioselective Synthesis of Oxazolidinones Using Carbon Dioxide
Junhyeon Choi1, Annaram Thirupathi1, Jihoon Kim1
1Department of Applied Chemistry, Kyung Hee University, Yongin 17104, Korea.
Abstract:
This study presents the application of a novel Fe-iminopyridine catalyst for the regioselective synthesis of oxazolidinones from carbon dioxide and aziridines. Our findings demonstrate that the Fe-iminopyridine catalyst containing imidazole functional group offers promising efficiency and facilitates a sustainable approach to green chemical synthesis at 50 °C and 10 bar CO2 pressure in a single-component Fe catalyst system. Various aziridines with carboxylic acid-derived substituents were transformed into 5-carbonyl substituted oxazolidinone products. The regioselective synthesis of oxazolidinones followed by the reduction enhances their utility for the pharmaceutically valuable compounds.
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