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Smartphone-Enabled Point-of-Care Testing for Prehospital Stroke Diagnosis
Paloma Menéndez-Valladares1,2,3, Rosa M Delgado1, David Núñez-Jurado1,3
1Neurovascular Research Group, Institute de Biomedicine of Seville, IBiS/Virgen Macarena University Hospital/CSIC/University of Seville, Seville, Spain.
Prehospital Emergency Care
|December 4, 2024
Summary
Point-of-care testing (POCT) for N-terminal pro-B-type natriuretic peptide (NT-proBNP) in ambulances can speed up stroke diagnosis. Smartphone integration further improves efficiency in prehospital stroke management.
Area of Science:
- Biomedical Engineering
- Emergency Medicine
- Clinical Diagnostics
Background:
- Stroke diagnosis requires rapid assessment for effective treatment.
- Prehospital diagnostic tools are crucial for timely intervention.
- N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a biomarker relevant to cardiovascular conditions, potentially aiding in differential diagnosis of stroke.
Purpose of the Study:
- To assess the feasibility of using point-of-care testing (POCT) devices for NT-proBNP measurement in prehospital settings.
- To evaluate the potential of POCT to expedite stroke diagnosis and improve patient care.
- To explore the integration of smartphone technology with POCT for enhanced prehospital stroke management.
Main Methods:
- Collected prehospital blood samples from suspected stroke patients.
- Measured NT-proBNP levels using a POCT device in ambulances and hospitals.
- Analyzed NT-proBNP POCT results and correlated them with smartphone images and laboratory immunoassay.
- Assessed the stability of NT-proBNP in collected samples.
Main Results:
- A strong correlation (R=0.926) was found between NT-proBNP POCT and standard immunoassay.
- Smartphone images showed high correlation with POCT values at 10 and 15 minutes (R²=0.9716 and R²=0.9405, respectively).
- NT-proBNP POCT demonstrated consistent results from whole blood and plasma samples (R=0.907).
Conclusions:
- NT-proBNP POCT devices are feasible for use in ambulances, potentially enabling stroke diagnosis within 10 minutes.
- The integration of smartphone technology with POCT offers a significant advancement in prehospital stroke management.
- This approach can lead to quicker and more effective patient care for suspected stroke cases.
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