Prognostic value of preoperative D-dimer to albumin ratio in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy
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View abstract on PubMed
Summary
This summary is machine-generated.The DDI-to-albumin ratio (DAR) is a valuable prognostic marker for locally advanced rectal cancer (LARC) patients undergoing neoadjuvant chemoradiotherapy. Higher DAR levels correlate with poorer overall survival and disease-free survival outcomes.
Area Of Science
- Oncology
- Biomarkers
- Rectal Cancer Research
Background
- Albumin and D-dimer have established prognostic value in various cancers.
- The predictive role of the DDI-to-albumin ratio (DAR) in locally advanced rectal cancer (LARC) is not well-defined.
Purpose Of The Study
- To evaluate the prognostic significance of the DAR in patients with LARC.
- To determine if DAR can predict treatment outcomes in LARC.
Main Methods
- Analysis of 513 LARC patients treated with neoadjuvant chemoradiotherapy (nCRT) and total mesorectal excision (TME).
- Patients were categorized into high (DAR > 0.016) and low (DAR ≤ 0.016) DAR groups based on ROC analysis.
- Prognostic value of DAR for overall survival (OS) and disease-free survival (DFS) was assessed.
Main Results
- The 5-year OS rates were 89.4% for low DAR and 80.9% for high DAR (p=0.013).
- The 5-year DFS rates were 85.7% for low DAR and 77.4% for high DAR (p=0.027).
- Multivariate analysis confirmed DAR as an independent prognostic factor for OS and DFS; nomograms including DAR improved predictive accuracy.
Conclusions
- The DAR is a highly usable and significant prognostic indicator for OS and DFS in LARC patients receiving nCRT.
- DAR can effectively predict outcomes for LARC patients undergoing neoadjuvant chemoradiotherapy.
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