Scalable Photonic Nose Development through Corona Phase Molecular Recognition

Area of Science:

• Nanotechnology and Sensor Development
• Biomedical Engineering
• Chemical Sensing

Background:

• Breath sensors offer noninvasive disease diagnosis but face scalability and data extraction challenges.
• Current designs limit array size (10-20 channels) due to material constraints and functionalization complexity.
• Need for advanced methods to create larger, more sensitive, and selective breath analysis arrays.

Purpose of the Study:

• To propose a new breath sensing array design process using Corona Phase Molecular Recognition (CoPhMoRe).
• To enable the creation of expansive nanoparticle interface libraries for broad multi-analyte detection.
• To outline critical milestones for translating CoPhMoRe into clinical breath sensor applications.

Main Methods:

• Utilizing Corona Phase Molecular Recognition (CoPhMoRe) for gas-phase sensing applications.
• Developing a CoPhMoRe-based photonic-nose sensor array concept.
• Leveraging fluorescent nanomaterials, specifically near-infrared single-walled carbon nanotubes.

Main Results:

• CoPhMoRe enables the creation of an expansive library of nanoparticle interfaces.
• The method facilitates broad fingerprints for detecting multiple analytes in breath.
• Demonstrated potential for CoPhMoRe in gas-phase sensing for breath analysis.

Conclusions:

• CoPhMoRe offers a scalable solution for developing advanced breath sensor arrays.
• This approach can overcome limitations of current breath sensor technology for clinical use.
• Identified key milestones are crucial for the practical clinical translation of CoPhMoRe breath sensors.