Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

616
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
616
Disorders of Hemostasis01:24

Disorders of Hemostasis

707
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
707
Coagulation01:09

Coagulation

4.7K
The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
4.7K
Cancer Therapies02:49

Cancer Therapies

7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

5.5K
Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
5.5K
Cancer Survival Analysis01:21

Cancer Survival Analysis

328
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
328

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Frailty in Cardiac Surgery-Is It the Missing Link in the Era of Precision Medicine.

Anesthesia and analgesia·2026
Same author

Frequent police contact and nonfatal overdose among people who use drugs in rural Appalachia.

Drug and alcohol dependence·2026
Same author

Quality of life during electronic patient-reported outcome (ePRO) monitoring in thoracic surgery patients: a pilot randomized controlled trial.

Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2026
Same author

Protocol for pro-inflammatory microRNA motif discovery using machine learning.

STAR protocols·2026
Same author

TLR7 inhibition limits cardiac ischemic injury by disrupting ITGAM-dependent immune-endothelial interaction.

bioRxiv : the preprint server for biology·2026
Same author

Impact of Hypobaria and Hypoxia Exposure on Mortality, Inflammation, and Coagulopathy in an Animal Model of Polytrauma.

Military medicine·2026

Related Experiment Video

Updated: Jun 5, 2025

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

29.9K

Cancer-Related Coagulopathy and Perioperative Considerations.

Seema P Deshpande1, Reney A Henderson1, Aniruddh U Ajith2

  • 1From the Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland.

Anesthesia and Analgesia
|December 4, 2024
PubMed
Summary
This summary is machine-generated.

Cancer patients exhibit complex coagulation issues, increasing risks for bleeding and clotting. Anesthesiologists must understand these hemostatic system derangements for optimal surgical care in this growing patient group.

More Related Videos

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.1K
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

11.9K

Related Experiment Videos

Last Updated: Jun 5, 2025

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

29.9K
Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
04:40

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models

Published on: January 5, 2024

2.1K
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

11.9K

Area of Science:

  • Oncology
  • Hematology
  • Anesthesiology

Background:

  • Cancer patients frequently develop complex coagulation abnormalities, impacting the hemostatic system.
  • These abnormalities elevate risks for thrombotic and hemorrhagic complications, increasing morbidity and mortality.
  • Improved cancer therapies enhance patient survival, leading to a larger population requiring surgical interventions.

Purpose of the Study:

  • To highlight the critical need for anesthesiologists to understand cancer-related coagulation derangements.
  • To provide insights into the types, pathophysiology, and clinical presentation of these abnormalities.
  • To emphasize optimizing perioperative management for cancer patients undergoing surgery.

Main Methods:

  • This study is a review of current literature on cancer-related coagulation abnormalities.
  • It synthesizes information on the pathophysiology and clinical implications.
  • Focuses on the perioperative considerations for anesthesiologists.

Main Results:

  • Cancer-related coagulation disorders are complex and prevalent.
  • These disorders significantly increase perioperative risks.
  • Understanding these derangements is crucial for effective patient management.

Conclusions:

  • Cancer-related coagulation abnormalities pose significant challenges in surgical settings.
  • Anesthesiologists require comprehensive knowledge of these hemostatic dysregulations.
  • Optimized perioperative care is essential for improving outcomes in this patient population.