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Injectable Minoxidil for Hair Loss Disorders: A Systematic Review.
Journal of Drugs in Dermatology : JDD
|December 4, 2024
Summary
Injectable minoxidil shows promise for treating androgenetic alopecia, with variable results for alopecia areata. This review analyzes its efficacy and safety in hair loss treatment.
Area of Science:
- Dermatology
- Pharmacology
Background:
- Topical and oral minoxidil are established hair loss treatments.
- A comprehensive review of injectable minoxidil's use is lacking.
Approach:
- Systematic review of 11 articles (19,192 patients).
- Included 5 RCTs, 1 CT, 2 retrospective studies, and 3 case reports.
- Analyzed androgenetic alopecia and alopecia areata in all age groups and genders.
Key Points:
- Injectable minoxidil significantly improved hair growth in androgenetic alopecia (P>0.05).
- Alopecia areata outcomes were variable; two of four studies showed significant improvement.
- Primary side effects included hypotension and pain; data on scarring hair loss is limited.
Conclusions:
- Injectable minoxidil is effective and safe for androgenetic alopecia.
- It shows variable efficacy and safety for alopecia areata.
- Further research is needed to optimize dosing and understand pharmacokinetic translation to clinical efficacy.
