Non-coding rnas in Turner syndrome: a systematic review
Júlio César Carvalho de Oliveira1, Eldevan da Silva Barbosa1, Nathaniel Batista Silva1
1Universidade Estadual do Maranhão, Zé Doca, MA, Brazil.
Summary
Non-coding RNAs (ncRNAs) like miRNAs and lncRNAs are linked to Turner syndrome (TS) clinical features, including ovarian development and X chromosome inactivation. These molecules may serve as valuable biomarkers for TS patient care.
Area of Science:
- Genetics
- Molecular Biology
- Endocrinology
Background:
- Turner syndrome (TS) is a chromosomal disorder affecting females, characterized by diverse clinical manifestations.
- Non-coding RNAs (ncRNAs) are increasingly recognized for their regulatory roles in gene expression and cellular processes.
- Understanding the involvement of ncRNAs in TS pathogenesis is crucial for identifying potential diagnostic and therapeutic targets.
Purpose of the Study:
- To review and synthesize findings on non-coding RNAs (ncRNAs) in Turner syndrome (TS).
- To correlate specific ncRNAs with clinical manifestations observed in TS patients.
- To explore the potential of ncRNAs as biomarkers in TS.
Main Methods:
- Systematic literature search of PubMed, SciELO, and ScienceDirect databases (2014-2023).
- Inclusion of original English articles focusing on ncRNAs (lncRNAs, miRNAs, circRNAs) and Turner syndrome.
- Analysis of studies linking ncRNAs to clinical characteristics of TS patients.
Main Results:
- Specific microRNAs (miRNAs) like miR-486-5p and miR-320a are associated with ovarian development.
- Other miRNAs (miR-126-3p, miR-126-5p) correlate with increased aortic stiffness.
- Downregulation of XIST (long non-coding RNA) suggests X chromosome inactivation dysfunction.
- Circular RNAs (circRNAs) are implicated in immune function and cardiac development.
Conclusions:
- ncRNAs play significant roles in key processes related to TS clinical features.
- These ncRNAs show promise as potential biomarkers for Turner syndrome.
- Further research may lead to novel clinical applications for ncRNAs in managing TS.
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