Meningoencephalitis caused by Histoplasma capsulatum complicating pregnancy

We report what appears to be the first established case of disseminated histoplasmosis in pregnancy. Involvement of the central nervous system made treatment difficult, and the course of disease required iatrogenic preterm delivery of an uninfected fetus. Aspects of pathogenesis, diagnosis, interaction with pregnancy, and treatment for this common infection, hitherto unreported in pregnancy, are presented.