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TISSUE GLUE-ASSISTED PLAQUE RADIOTHERAPY FOR CHOROIDAL TUMORS WITH SCLERAL THINNING.

Carol L Shields¹, Rhea Suribhatla¹, Mark Romero¹

¹Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania; and.

Retina (Philadelphia, Pa.)

|December 4, 2024

Summary

Tissue glue-assisted plaque radiotherapy effectively treats choroidal tumors in patients with thin sclera. This method ensures accurate placement and stability, leading to significant tumor regression without complications.

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Area of Science:

Ophthalmology
Radiation Oncology
Oncology

Background:

Choroidal tumors, including melanoma and metastasis, pose treatment challenges, especially when associated with scleral thinning.
Scleral thinning can compromise the stability and accuracy of plaque radiotherapy placement.
Novel techniques are needed to ensure safe and effective radiation delivery for these complex cases.

Purpose of the Study:

To evaluate the accuracy, stability, and long-term outcomes of tissue glue-assisted plaque radiotherapy for choroidal tumors.
To assess the safety and efficacy of using tissue glue in cases with scleral thinning.

Main Methods:

A retrospective evaluation of patients undergoing tissue glue-assisted plaque radiotherapy at an ocular oncology center.
Data collected included patient demographics, tumor characteristics, surgical details, tumor response, and complications.
Ultrasonography was used to confirm accurate plaque placement.

Main Results:

Thirteen patients (mean age 72) with choroidal melanoma or metastasis and scleral thinning were treated.
Tissue glue ensured accurate and stable plaque placement throughout the mean 113-hour treatment duration.
At 12 months, mean tumor thickness decreased by 36% (to 2.7 mm), with no glue-related or scleral complications.

Conclusions:

Tissue glue-assisted plaque radiotherapy is a safe and effective treatment for choroidal tumors in patients with compromised scleral integrity.
This technique provides accurate, stable plaque placement and favorable tumor response.
No significant complications were observed, highlighting the safety profile of this approach.