Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Typical Model Studies01:30

Typical Model Studies

340
Fluid mechanics model studies often utilize scaled-down systems to predict fluid behavior in full-scale environments, such as river flows, dam spillways, and structures interacting with open surfaces. Maintaining Froude number similarity in river models is crucial, as it replicates surface flow features like wave patterns and velocities.
340
Fluid Pressure over Curved Plate of Constant Width01:12

Fluid Pressure over Curved Plate of Constant Width

1.2K
When a curved plate of constant width is submerged in a liquid, the pressure acting normal to the plate varies continuously both in magnitude and direction. Calculating the magnitude and location of the resultant force at a point is often challenging for such cases. One of the methods to determine the resultant force and its location involves separately calculating the horizontal and vertical components of the resultant force. This complex calculation can be simplified by representing the...
1.2K
Design Example: Creating a Hydraulic Model of a Dam Spillway01:21

Design Example: Creating a Hydraulic Model of a Dam Spillway

124
Scaled hydraulic models of dam spillways provide a practical way to replicate and study the intricate flow dynamics of these structures. Often built to a 1:15 ratio, these models allow for observing critical water behavior, such as velocity distribution, flow patterns, and energy dissipation.
124
Modeling and Similitude01:12

Modeling and Similitude

245
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
245
Pressure Variation in a Fluid at Rest01:11

Pressure Variation in a Fluid at Rest

220
In a fluid at rest, the pressure at any point beneath the fluid surface depends solely on the depth, not on the container's shape or size. This principle, known as hydrostatic pressure, arises because, in stationary fluids, there is no acceleration, meaning the forces within the fluid balance out. Only vertical forces, caused by the weight of the fluid above, contribute to pressure changes with depth.
When measuring pressure at two different levels within the fluid, the difference in...
220
Fluid Pressure over Flat Plate of Variable Width01:02

Fluid Pressure over Flat Plate of Variable Width

1.3K
When a flat plate is submerged in a fluid, the fluid exerts pressure on the plate. This pressure can lead to many different phenomena, including drag and buoyancy. To understand the behavior of the fluid over a flat plate of variable width, it is essential to analyze the distribution of the pressure exerted.
The pressure distribution on the plate can be calculated by determining the force that acts on a differential area strip of the plate. Thus, the magnitude of the force is equal to the...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia.

American journal of reproductive immunology (New York, N.Y. : 1989)·2011
Same author

Destabilization of coxsackievirus b3 genome integrated with enhanced green fluorescent protein gene.

Intervirology·2011
Same author

[Clinicopathological features of primary splenic histiocytic sarcoma: a case report and literature review].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2011
Same author

[Comparison of treatment with micro endoscopic discectomy and posterior lumbar interbody fusion using single and double B-Twin expandable spinal spacer].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2011
Same author

Virtual transplantation in designing a facial prosthesis for extensive maxillofacial defects that cross the facial midline using computer-assisted technology.

The International journal of prosthodontics·2011
Same author

Total synthesis of phorboxazole A via de novo oxazole formation: convergent total synthesis.

Journal of the American Chemical Society·2010

Related Experiment Video

Updated: Jun 5, 2025

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

1.6K

Three-dimensional fluid-structure interaction modelling of the venous valve using immersed boundary/finite element

Bo Wang1, Liuyang Feng2, Lei Xu3

  • 1Research Center for Mathematics and Interdisciplinary Sciences, Shandong University, Qingdao, 266237, China.

Computers in Biology and Medicine
|December 4, 2024
PubMed
Summary
This summary is machine-generated.

This study uses 3D simulations to model blood flow and valve interactions in veins. Findings reveal how valve movement, pressure, and disease-related changes impact venous hemodynamics.

Keywords:
Fluid–structure interactionImmersed-boundary finite element methodThree-dimensional frameworkVenous valve

More Related Videos

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
06:18

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

447
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.4K

Related Experiment Videos

Last Updated: Jun 5, 2025

In Silico Clinical Trials for Cardiovascular Disease
09:09

In Silico Clinical Trials for Cardiovascular Disease

Published on: May 27, 2022

1.6K
Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery
06:18

Intravascular Ultrasound Image-Based Finite Element Modeling Approach for Quantifying In Vivo Mechanical Properties of Human Coronary Artery

Published on: December 6, 2024

447
Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

6.4K

Area of Science:

  • Biomedical Engineering
  • Fluid Dynamics
  • Computational Biology

Background:

  • Venous diseases like varicose veins and deep vein thrombosis significantly impact patient health and require better understanding for clinical management.
  • Current research often relies on simplified models, necessitating advanced computational approaches to accurately capture complex venous hemodynamics.

Purpose of the Study:

  • To develop and utilize a 3D numerical simulation framework to investigate fluid-structure interaction (FSI) between blood flow and venous valves.
  • To analyze the dynamic behavior of venous valves and blood flow, and quantify key physiological parameters throughout the cardiac cycle.
  • To explore the mechanisms underlying venous diseases, including the impact of hydrostatic pressure and valve structural changes.

Main Methods:

  • A three-dimensional (3D) numerical simulation employing the immersed boundary/finite element method.
  • Utilized a hyperelastic constitutive model to simulate the incompressible, nonlinear mechanical response of venous valves.
  • Analyzed fluid-structure interaction (FSI) between blood flow and venous valves, including stress-strain distribution.

Main Results:

  • Demonstrated periodic valve movement and blood flow patterns synchronized with the cardiac cycle.
  • Quantified physiological parameters: blood pressure, flow rate, and geometric orifice area.
  • Identified significant correlation between dynamic valve motion and vortex formation; revealed stress/strain concentration at valve free edges, differing from 2D models.
  • Established increased hydrostatic venous pressure as a primary driver of venous vessel dilation.
  • Compared the hemodynamic effects of venous valve fibrosis and atrophy.

Conclusions:

  • The 3D FSI framework provides a comprehensive model for the venous system, crucial for understanding venous disease mechanisms.
  • Findings offer critical insights into the development and progression of venous diseases, supporting prevention, diagnosis, and treatment strategies.
  • Highlights the importance of 3D modeling for accurately capturing venous hemodynamics and valve function.