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Sarcopenia in older people with multiple sclerosis: A cross-sectional study
Tobias Gaemelke1, Ida S Pedersen2, Ulrik Dalgas1
1Exercise Biology, Department of Public Health, Aarhus University, Aarhus, Denmark.
Multiple Sclerosis and Related Disorders
|December 4, 2024
Summary
Diagnosing sarcopenia in older people with multiple sclerosis (pwMS) is more accurate using lower extremity tests. This approach better identifies reduced muscle mass and strength, crucial for managing sarcopenia in this population.
Area of Science:
- Gerontology
- Neurology
- Kinesiology
Background:
- Older adults with multiple sclerosis (pwMS) represent over a third of the MS population.
- Aging and MS symptoms can increase the risk of sarcopenia, characterized by muscle loss and weakness.
- The impact of sarcopenia on older pwMS is understudied.
Purpose of the Study:
- To determine how sarcopenia diagnosis in older pwMS is affected by using upper versus lower extremity tests.
- To compare the sensitivity of different diagnostic approaches for sarcopenia in older pwMS using the EWGSOP2 criteria.
Main Methods:
- A cross-sectional study analyzed data from 41 older pwMS and 27 healthy controls (HC).
- Sarcopenia was assessed using the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) diagnostic tools.
- Lower extremity muscle strength tests were specifically included.
Main Results:
- Older pwMS exhibited significantly lower muscle mass and strength in their lower extremities compared to HC.
- While 15% of older pwMS had sarcopenic muscle mass, only 5% were diagnosed with sarcopenia.
- Reduced upper extremity strength was found in 5% and lower extremity strength in 7% of older pwMS.
Conclusions:
- Sarcopenia diagnosis in older pwMS is more sensitive when utilizing lower extremity strength tests.
- Lower extremity assessments are recommended for evaluating sarcopenia in older pwMS due to their greater impact.
- This highlights the importance of targeted diagnostic tools for this specific demographic.
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