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Repair of replication-dependent double-strand breaks differs between the leading and lagging strands

Michael T Kimble1, Aakanksha Sane2, Robert J D Reid3

  • 1Program in Biological Sciences, Columbia University, New York, NY 10027, USA; Department of Microbiology & Immunology, Columbia University Irving Medical Center, New York, NY 10032, USA.

Molecular Cell
|December 4, 2024
PubMed
Summary

DNA replication can turn single-strand breaks into double-strand breaks (DSBs). The replication-coupled nucleosome assembly pathway, particularly histone H3K56 acetylation, is crucial for repairing these replication-dependent DSBs.

Keywords:
DNA replicationH3K56 acetylationMms22Mre11Rad51Rtt109homologous recombination

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