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Terpenoids mediated cell apoptotsis in cervical cancer: Mechanisms, advances and prospects

Peng Zhang1, Hong Liu1, Yuan Yu1

  • 1School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, Sichuan Province, China.

Fitoterapia
|December 4, 2024
PubMed
Abstract

Insights

Terpenoids show promise in preventing cervical cancer by promoting cancer cell death and enhancing chemotherapy effectiveness. Further research is needed to explore their full therapeutic potential and clinical applications.

Area of Science:

  • Natural Products Chemistry
  • Oncology
  • Molecular Biology

Background:

  • Cervical cancer is a leading global malignancy, particularly in developing nations.
  • Existing prevention strategies like vaccination and screening have limitations.
  • High incidence necessitates novel therapeutic and prophylactic approaches.

Purpose of the Study:

  • To systematically review terpenoids for cervical cancer prevention.
  • To elucidate terpenoid mechanisms in cervical cancer prophylaxis and treatment.
  • To identify limitations in current research on terpenoids for cervical cancer.

Main Methods:

  • Systematic literature review of studies on terpenoids and cervical cancer.
  • Analysis of identified terpenoids' mechanisms of action.
  • Evaluation of current research limitations and future directions.

Main Results:

  • Terpenoids reduce cervical cancer incidence and induce cancer cell apoptosis.
  • Mechanisms involve PI3K/AKT, endoplasmic reticulum stress (ERS), and mitochondria-dependent pathways.
  • Some terpenoids improve chemotherapy sensitivity and patient quality of life.

Conclusions:

  • Terpenoids significantly inhibit cervical cancer progression.
  • Diverse terpenoids exhibit complex mechanisms requiring further investigation.
  • Clinical trials and applications can be advanced by understanding specific targets and bioactivities.
Keywords:
ApoptosisBiosynthesisCervical cancerRegulatory pathwaysTerpenoids

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