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Anticholinergics and human brain stem auditory evoked potentials.

S K Samra, M M Morris

    The American Journal of Otology
    |March 1, 1986
    PubMed
    Summary
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    Premedication with morphine and glycopyrrolate did not significantly alter brain stem auditory evoked potentials. Morphine and scopolamine showed inconclusive effects on auditory evoked potentials due to variability.

    Area of Science:

    • Anesthesiology and Pharmacology
    • Neuroscience
    • Audiology

    Background:

    • Brain stem auditory evoked potentials (BAEPs) assess auditory pathway function.
    • Premedication is common in anesthesia to manage patient comfort and physiological responses.
    • Anticholinergic drugs and opioids like morphine are frequently used in premedication regimens.

    Purpose of the Study:

    • To investigate the impact of morphine and specific anticholinergic drugs (glycopyrrolate, scopolamine) on BAEP latencies.
    • To determine if these premedications alter the neural conduction times within the auditory pathway.

    Main Methods:

    • Thirty patients were included in the study.
    • Three groups were formed: morphine alone (control), morphine with glycopyrrolate, and morphine with scopolamine.

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  • Absolute and interpeak latencies of BAEPs were measured and compared across groups.

    • Main Results:

    • Premedication with morphine alone did not significantly change BAEP latencies.
    • Combination of morphine and glycopyrrolate also showed no significant effect on BAEP latencies.
    • Results for morphine and scopolamine were inconclusive due to substantial intersubject variability.

    Conclusions:

    • Morphine and glycopyrrolate premedication appear to have minimal impact on BAEPs.
    • The effects of morphine and scopolamine on BAEPs require further investigation due to observed variability.