Related Experiment Video

Updated: Jun 5, 2025

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.5K

Prevalence of potentially inappropriate prescriptions identified using screening tools in paediatric patients: a

Shamala Balan1, Norkasihan Ibrahim2,3

  • 1Pharmacy Department, Hospital Tengku Ampuan Rahimah, Klang, Malaysia shamala.balan@gmail.com.

European Journal of Hospital Pharmacy : Science and Practice
|December 4, 2024
PubMed

Insights

Potentially inappropriate prescriptions are common in children, with prevalence varying widely. Developing specific tools for age and conditions is crucial for better evaluation and understanding the economic impact.

Area of Science:

  • Pediatric Pharmacology
  • Medication Safety
  • Health Services Research

Background:

  • Inappropriate prescriptions contribute to medication-related problems.
  • Prevalence of inappropriate prescriptions in pediatric patients is not well-understood.

Purpose of the Study:

  • To systematically review the prevalence of potentially inappropriate prescriptions in pediatric patients.
  • To identify and evaluate tools used for detecting inappropriate prescriptions in children.
  • To delineate the strengths and limitations of these identification tools.

Main Methods:

  • Systematic literature search of PubMed, CINAHL, Cochrane, and Google Scholar databases.
  • Inclusion of English-language studies published until May 2023.
  • Thematic analysis of eligible articles, assessing methodological quality.

Main Results:

  • Twelve high-quality studies were included.
  • Prevalence of potentially inappropriate medications (PIMs) ranged from 0.04% to 69%, and potential prescribing omissions (PPOs) from 1.5% to 55.9%.
  • Age was a key predictor, with PIMs more common in 2-6 year olds and PPOs in 6-12 year olds. The POPI tool was most frequently used.

Conclusions:

  • Potentially inappropriate prescriptions are highly prevalent in pediatric patients.
  • Existing tools show wide variability in reported prevalence and limited practical implementation.
  • Future research should focus on developing and implementing age-, disease-, or country-specific tools to improve evaluation and economic impact assessment.
Abstract

Keywords:
HEALTH SERVICES ADMINISTRATIONPEDIATRICSPHARMACY SERVICE, HOSPITALSafetyTherapeutic Use

More Related Videos

Using an Automated Hirschberg Test App to Evaluate Ocular Alignment05:40

Using an Automated Hirschberg Test App to Evaluate Ocular Alignment

Published on: March 24, 2020

11.5K
Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children04:55

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

10.8K

Related Concept Videos

Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
690
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
773
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
81
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
437
Preventive Healthcare Services01:30

Preventive Healthcare Services

Preventive healthcare services keep people healthy via frequent check-ups, screening, and counseling. They primarily aid in disease prevention rather than treating an acute or chronic illness. Preventive treatment also keeps individuals productive and energetic, allowing them to work well into their retirement years. Examples of preventive care services include:
967