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Related Experiment Video

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Genetically Supported Causality between Brain Structural Connectome and Sleep Duration in Children: A Two-Sample

Ruijie Zhang1, Liyan Luo2, Lu Zhang1

  • 1Department of Neonatology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.

Eneuro
|December 4, 2024
PubMed
Summary

Investigating brain connections and children's sleep duration using Mendelian randomization revealed specific causal links. Certain left hemisphere connections correlate with shorter sleep, while right hemisphere connections to the thalamus are linked to longer sleep.

Keywords:
Mendelian randomizationbrain networkschildrensleep durationstructural connectivity

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Area of Science:

  • Neuroscience
  • Genetics
  • Sleep Science

Background:

  • Structural brain connections are known to influence sleep duration in children.
  • However, the precise causal relationships between various brain regions and sleep duration remain incompletely understood.

Purpose of the Study:

  • To investigate the causal relationships between 206 structural brain connections and sleep duration in children.
  • To utilize a two-sample Mendelian randomization analysis for robust causal inference.

Main Methods:

  • Conducted a two-sample Mendelian randomization analysis using genome-wide association study (GWAS) data.
  • Examined associations between 206 white-matter structural connectivity (SC) measures and children's sleep duration.
  • Performed sensitivity analyses to ensure the robustness of findings.

Main Results:

  • Stronger connectivity from the left hemisphere (LH) control network to the accumbens and from the LH somatomotor network to the LH default network were associated with shorter sleep durations.
  • Increased white-matter SC from several right hemisphere (RH) networks (dorsal attention, control, default, limbic, somatomotor) to the thalamus correlated with longer sleep durations.
  • Specific causal relationships between distinct brain structural connections and sleep duration in children were identified.

Conclusions:

  • Two-sample Mendelian randomization provides novel insights into brain-sleep duration relationships in children.
  • The study demonstrates a causal link between specific brain structural connections and variations in children's sleep duration.
  • Findings highlight the importance of specific neural pathways in regulating sleep in pediatric populations.