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Updated: Jun 5, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
One-Pot Aminomethylation of Heteroarenes by Rongalite as In Situ C1 Source
Sanjeeva Thunga1, Neetika Singh1, Naveenkumar Anugu1
1Department of Chemistry, National Institute of Technology Warangal, Warangal, Telangana 506004, India.
Abstract:
Rongalite-mediated one-pot aminomethylation of heteroarenes using secondary amines/anilines has been developed. This transition-metal-free and mild reaction offers an efficient way to synthesize aminomethylated heteroaromatic compounds with high yields and broad functional group tolerance. Here, Rongalite plays a key role in generating the C1 unit source in situ, which triggers the aminomethylation process. This approach provides a library of aminomethylated imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazoles.
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