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Related Experiment Videos

Lactate-induced panic in primary affective disorder.

D S Cowley, S R Dager, D L Dunner

    The American Journal of Psychiatry
    |May 1, 1986
    PubMed
    Summary

    Intravenous sodium lactate infusions triggered panic attacks in patients with depression and panic disorder. The similar panic response rates suggest lactate-induced panic is not specific to panic disorder diagnosis.

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    Area of Science:

    • Psychiatry
    • Neuroscience
    • Clinical Psychology

    Background:

    • Panic attacks are a core symptom of panic disorder and agoraphobia.
    • Sodium lactate infusion is a known method for provoking panic attacks in susceptible individuals.
    • The diagnostic specificity of lactate-induced panic has been debated.

    Purpose of the Study:

    • To investigate the diagnostic specificity of sodium lactate-induced panic attacks.
    • To compare panic responses to intravenous sodium lactate in patients with primary depression and secondary panic attacks versus those with panic disorder or agoraphobia.

    Main Methods:

    • Intravenous sodium lactate administration.
    • Inclusion of patients diagnosed with primary depression and secondary panic attacks (n=7).
    • Inclusion of patients diagnosed with panic disorder or agoraphobia with panic attacks (n=26).
    • Assessment of panic responses in both groups.

    Main Results:

    • Both patient groups exhibited similar rates of panic response following sodium lactate infusion.
    • The findings indicate a comparable susceptibility to lactate-induced panic across the studied groups.

    Conclusions:

    • The diagnostic specificity of lactate-induced panic is challenged by these findings.
    • Panic responses to sodium lactate may not be exclusive to panic disorder, suggesting broader implications for understanding panic symptomatology.

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