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Updated: Jun 5, 2025

Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
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TRPM channels in human cancers: regulatory mechanism and therapeutic prospects

Qinfeng Liu1, Mengyu Hu1, Shi Li1

  • 1National "111" Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education & Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, 430074, China.

Biomarker Research
|December 5, 2024
PubMed

Insights

Transient Receptor Potential Melastatin (TRPM) channels are increasingly linked to cancer, influencing tumor growth and metastasis. Targeting TRPM channels offers potential new strategies for cancer treatment and immunotherapy.

Area of Science:

  • Molecular Biology
  • Oncology
  • Ion Channel Physiology

Background:

  • Transient Receptor Potential Melastatin (TRPM) channels are implicated in diseases, including cancer.
  • TRPM channels exhibit both pro- and anti-tumorigenic functions in various malignancies.
  • They are involved in tumor cell proliferation, survival, invasion, and metastasis, acting as potential biomarkers.

Purpose of the Study:

  • To describe the structure and physiological functions of TRPM channel family members.
  • To outline the roles of TRPM channels in common cancers like pancreatic, prostate, colorectal, breast, brain cancer, and melanoma.
  • To investigate the mechanisms of TRPM channel involvement in tumorigenesis from the tumor microenvironment and intracellular signaling.

Main Methods:

  • Literature review and analysis of existing research on TRPM channels in cancer.
  • Examination of TRPM channel involvement in tumor cell functions, including proliferation, survival, invasion, and metastasis.
  • Analysis of TRPM channel roles in signaling pathways (Wnt/β-catenin, MAPK, PI3K/AKT, p53, autophagy) and the tumor microenvironment.

Main Results:

  • TRPM channels are involved in tumor cell proliferation, survival, invasion, and metastasis.
  • They mediate extracellular matrix remodeling, aiding malignant transformation.
  • TRPM channels regulate ion inflow and participate in key cancer signaling pathways.

Conclusions:

  • TRPM channels are crucial in cancer development and progression.
  • Targeting TRPM channels presents therapeutic opportunities and challenges in cancer treatment.
  • Combining TRPM channel-targeted drugs with cancer immunotherapy is a promising future direction.
Keywords:
AutophagyCancer progressionSignaling pathwayTRPM channelsTargeted tumor therapyTumor microenvironment

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