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Updated: Jun 5, 2025

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
microRNA and Hypertension
Lishu He1,2, Yong Liu1, Michael E Widlansky3
1Department of Physiology, University of Arizona College of Medicine-Tucson (L.H., Y.L., Q.Q., M.L.).
Abstract:
Several microRNAs (miRNAs) strongly influence blood pressure and the development of hypertension by modulating vascular, renal, and other physiological mechanisms. In addition, miRNAs may contribute to the genetic regulation of blood pressure. Future research should focus on investigating select miRNAs with potent physiological effects, understanding cellular context-dependent mechanisms conferring specificity to miRNA action, and integrating miRNAs as powerful modulators into the molecular system that underlies the regulation of blood pressure and the development of hypertension.
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