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Elevated systemic inflammation response index is associated with poor outcomes in minor ischemic stroke
Jie Li1,2, Ping Zhang1,2, Hong Chen1,2
1Department of Neurology, Deyang People's Hospital, Deyang, China.
Frontiers in Neurology
|December 5, 2024
Summary
Elevated systemic inflammation response index (SIRI) levels are linked to poor 90-day functional outcomes in patients with minor ischemic stroke (MIS). SIRI may help identify high-risk MIS patients for personalized treatment strategies.
Area of Science:
- Neurology
- Inflammation Research
- Biomarker Discovery
Background:
- Minor ischemic stroke (MIS) frequently leads to significant long-term disability.
- Identifying early indicators of poor functional outcomes in MIS patients is crucial for timely intervention.
Purpose of the Study:
- To investigate the association between the systemic inflammation response index (SIRI) and 3-month functional outcomes in patients diagnosed with MIS.
- To determine if SIRI can serve as a predictive biomarker for disability after MIS.
Main Methods:
- A prospective observational study enrolled 152 MIS patients (NIHSS score 0-3) within 24 hours of symptom onset.
- Systemic inflammation response index (SIRI) was measured from blood samples collected upon admission.
- Functional outcomes were assessed at 90 days using the modified Rankin Scale (mRS), with scores 2-6 indicating poor outcomes.
Main Results:
- 15.8% of MIS patients experienced poor outcomes at 90 days.
- Patients with poor outcomes exhibited significantly higher median SIRI levels (1.93) compared to those with good outcomes (1.21) (p=0.003).
- An elevated SIRI (>1.27 × 10^9/L) was independently associated with an increased risk of poor 90-day outcomes (OR: 1.57, p=0.010) and a significant risk factor (OR: 4.80, p=0.008) in multivariate analysis.
Conclusions:
- Elevated SIRI levels are common in MIS patients and are significantly associated with poor functional outcomes at 90 days.
- The SIRI demonstrates potential as a valuable biomarker for identifying MIS patients at higher risk of disability.
- Utilizing SIRI could aid in tailoring therapeutic decisions and stratifying patients in clinical trials for MIS.
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