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Elevated systemic inflammation response index is associated with poor outcomes in minor ischemic stroke

Jie Li1,2, Ping Zhang1,2, Hong Chen1,2

  • 1Department of Neurology, Deyang People's Hospital, Deyang, China.

Frontiers in Neurology
|December 5, 2024
PubMed
Abstract

Insights

Elevated systemic inflammation response index (SIRI) levels are linked to poor 90-day functional outcomes in patients with minor ischemic stroke (MIS). SIRI may help identify high-risk MIS patients for personalized treatment strategies.

Area of Science:

  • Neurology
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Minor ischemic stroke (MIS) frequently leads to significant long-term disability.
  • Identifying early indicators of poor functional outcomes in MIS patients is crucial for timely intervention.

Purpose of the Study:

  • To investigate the association between the systemic inflammation response index (SIRI) and 3-month functional outcomes in patients diagnosed with MIS.
  • To determine if SIRI can serve as a predictive biomarker for disability after MIS.

Main Methods:

  • A prospective observational study enrolled 152 MIS patients (NIHSS score 0-3) within 24 hours of symptom onset.
  • Systemic inflammation response index (SIRI) was measured from blood samples collected upon admission.
  • Functional outcomes were assessed at 90 days using the modified Rankin Scale (mRS), with scores 2-6 indicating poor outcomes.

Main Results:

  • 15.8% of MIS patients experienced poor outcomes at 90 days.
  • Patients with poor outcomes exhibited significantly higher median SIRI levels (1.93) compared to those with good outcomes (1.21) (p=0.003).
  • An elevated SIRI (>1.27 × 10^9/L) was independently associated with an increased risk of poor 90-day outcomes (OR: 1.57, p=0.010) and a significant risk factor (OR: 4.80, p=0.008) in multivariate analysis.

Conclusions:

  • Elevated SIRI levels are common in MIS patients and are significantly associated with poor functional outcomes at 90 days.
  • The SIRI demonstrates potential as a valuable biomarker for identifying MIS patients at higher risk of disability.
  • Utilizing SIRI could aid in tailoring therapeutic decisions and stratifying patients in clinical trials for MIS.
Keywords:
disabilityminor ischemic strokeodds ratioprognosissystemic inflammation response index

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