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Resistin concentrations in perivascular adipose tissue as a highly sensitive marker of smoking status in patients with advanced coronary artery disease requiring coronary artery bypass grafting

  • 0Department of Cardiac Surgery and Heart Transplantation, Institute of Heart Diseases, Wrocław Medical University, Wrocław, Poland.
Frontiers in Public Health +

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December 5, 2024

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December 5, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Smoking significantly elevates resistin in perivascular adipose tissue (PVAT) of coronary artery disease (CAD) patients. This finding highlights a dose-dependent relationship between smoking pack-years and PVAT resistin levels.

Area Of Science

  • Cardiovascular Research
  • Adipose Tissue Biology
  • Inflammation and Immunity

Background

  • Smoking is a major risk factor for coronary artery disease (CAD).
  • Smoking-induced chronic inflammation may affect endothelial function and adipokine secretion.
  • Perivascular adipose tissue (PVAT) resistin alterations in smokers with CAD are not well understood.

Purpose Of The Study

  • To investigate the association between resistin concentrations in PVAT and smoking status in CAD patients.
  • To determine if smoking influences PVAT resistin levels in patients undergoing coronary artery bypass grafting (CABG).

Main Methods

  • 110 advanced CAD patients undergoing CABG were analyzed.
  • Patients were classified as never-smokers or ever-smokers (current/past).
  • PVAT and plasma resistin, plasma IL-6, and hs-CRP were measured via ELISA.

Main Results

  • PVAT resistin was significantly higher in ever-smokers versus never-smokers (p < 0.0001).
  • PVAT resistin positively correlated with pack-years (p < 0.0001), plasma resistin (p < 0.0001), and IL-6 (p < 0.0001).
  • Smoking, pack-years, plasma resistin, and IL-6 were independent predictors of elevated PVAT resistin.

Conclusions

  • Smoking status is positively associated with PVAT resistin concentrations in advanced CAD patients.
  • A clear dose-dependent relationship exists between smoking and PVAT resistin levels.
  • Elevated PVAT resistin in smokers may contribute to CAD pathogenesis.

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