Cardiac involvement in dermatological disorders: A narrative review

Area of Science:

• Dermatology and Cardiology
• Pathogenic Mechanisms
• Genetic and Acquired Conditions

Background:

• Growing evidence links skin conditions to cardiac issues.
• Dermatologists often manage patients with genetic skin disorders carrying cardiac risks.
• Cardiac complications can range from mild to life-threatening.

Purpose of the Study:

• To review primary cutaneous disorders with cardiac manifestations.
• To consolidate current knowledge on the skin-heart disease connection.
• To emphasize the importance of recognizing cardiac involvement in dermatological patients.

Main Methods:

• Comprehensive narrative literature review.
• Searched PubMed and Google Scholar databases up to November 2023.
• Included original research, reviews, case reports, and case series.

Main Results:

• Identified links between skin disorders and cardiac issues like septal defects, cardiomyopathy, and valvular heart disease.
• Found associations across congenital diseases, inflammatory conditions, connective tissue disorders, and adverse drug reactions.
• Highlighted the spectrum of cardiac implications, some of which are life-threatening.

Conclusions:

• Skin conditions can be indicators of underlying cardiac disease.
• Integrated diagnosis and management of dermatological and cardiac conditions are essential.
• Timely intervention and patient counseling are critical for improving outcomes.