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Updated: Jun 5, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
BINAP-Accelerated Copper-Mediated Photochemical Late-Stage Trifluoromethylation of Arenes
Xueyan Yang1,2,3, Jiemin Wang3, Mengyao Pei3
1College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
Abstract:
Site-selective and late-stage C-H trifluoromethylation (including pentafluoroethylation) of arylthianthrenium salts using in situ generated CuCF3 from Ruppert-Prakash reagent under visible light was found to be significantly accelerated by a catalytic amount of rac-BINAP, allowing the reaction to complete within 15 min under very mild conditions without using any additional photoredox catalysts. The process showed a broad substrate scope, high efficiency, and excellent regioselectivity, which holds the promise to accelerate the discovery of fluorinated medicinal compounds.
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